抗精神病药物处方模式和第一发精神病的决定因素:来自赞比亚的2019-2024年横截面研究
Lihlizulu Thabo Moyo1, Thandiwe Martha Tembo1, Brian Maila2,3
1Chainama Hills College Hospital, P.O. Box 30043, Lusaka, Zambia.
BMC psychiatry
|January 30, 2026
概括
在赞比亚,首发精神病治疗表明人们更喜欢使用较旧的抗精神病药物,这取决于患者的性别和坚持. 这凸显了需要制定政策来改善获得新,有效药物的机会.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 全球健康 全球健康
背景情况:
- 第一发精神病 (FEP) 是心理障碍干预的关键时期,对长期结果产生重大影响.
- 抗精神病药物是FEP管理的基石,但由于患者和资源因素,处方模式在全球范围内有所不同.
- 了解赞比亚的当地处方做法对于优化FEP护理至关重要.
研究的目的:
- 在赞比亚,在FEP的成年人中描述抗精神病药物处方模式.
- 确定与使用第二代抗精神病药物 (SGA) 相关的人口和治疗相关因素.
主要方法:
- 在赞比亚卢萨卡的Chainama Hills大学医院对FEP患者 (2019-2024) 的213个成年医疗记录进行了横截面审查.
- 数据抽象包括社会人口统计,临床和处方信息.
- 多变量逻辑回归分析了与SGA相关的因素与第一代抗精神病药物 (FGA) 处方.
主要成果:
- 最常见的诊断是其他精神病 (54.0%) 和短暂/急性精神病 (34.7%).
- 首代抗精神病药物 (FGA) 如普罗马зин和哈洛佩里多尔是最常被处方的,其次是SGArisperidone.
- 女性性别 (AOR=7.55) 增加了SGA处方的几率,而部分治疗坚持 (AOR=0.39) 减少了它.
结论:
- 赞比亚FEP治疗中存在FGA的偏好,受性别和坚持的影响.
- 处方决定似乎是务实的,以药物的可用性和可负担性在低资源环境中形成.
- 需要采取政策干预措施,以促进基于证据的处方,整合性别敏感和专注于坚持的护理,并提高获得有效抗精神病药物的机会.
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