人类乳头瘤病毒 (HPV) - - 在一个多民族发展中国家的头角状细胞癌 (HNSCC) 驱动
Hans Prakash Sathasivam1, Rohaizam Japar2, Zanariah Alias2
1National Institutes of Health, Ministry of Health, Jalan Setia Murni U13/52, Seksyen U13 Setia Alam, Shah Alam, 40170, Malaysia. hans@moh.gov.my.
BMC cancer
|January 30, 2026
概括
人类乳头瘤病毒 (HPV) 驱动的头角状细胞癌 (HNSCC) 在口腔瘤中很普遍. 与HPVDNA测试的RNA in situ杂交 (RNAISH) 或p16免疫组织化学 (IHC) 可以识别HPV驱动的HNSCC,以更好地分层患者.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 头角状细胞癌 (HNSCC) 是一种常见的癌症.
- 一个重要的HNSCC子集归因于人类乳头瘤病毒 (HPV).
- 在低收入和中等收入国家,关于HPV驱动的HNSCC的数据有限.
研究的目的:
- 为了确定HPV驱动的HNSCC在多中心队列中的流行率.
- 评估不同HPV检测方法 (RNAISH,p16 IHC,HPV DNA) 的实用性.
- 评估这些方法对患者结果的预后价值.
主要方法:
- 一项跨部门多中心研究包括356名患有初级HNSCC的成年患者 (2016-2020年).
- 使用RNA in situ杂交 (RNAISH) 检测出高风险的HPVmRNA.
- 还进行了INK4a免疫组织化学 (IHC) 和HPV DNA (HPVDNA) 测试. 生存分析评估了预后效用.
主要成果:
- 由HPV驱动的HNSCC的患病率为11.0% (95% CI:7.9-14.7%).
- 由HPV驱动的HNSCC主要发生在口腔瘤中 (94.9%).
- 口腔,喉和喉下瘤不是由HPV驱动的.
结论:
- 在这个队列中,由HPV驱动的HNSCC主要是口腔,HPV16是最常见的基因型.
- 建议进行单个RNAISH测试或双重p16INK4a IHC和HPVDNA测试以确定HPV状态.
- 这些方法可以改善患者分层和临床结果,特别是在资源有限的环境中.
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