使用基因组规模分析揭示微生物,代谢物和饮食化合物之间的相互作用
Tong Wang1, Benjamin Gyori2,3,4, Scott T Weiss5
1Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Microbiome
|January 31, 2026
概括
肠道微生物表现出显著的代谢变化,一些饮食化合物被许多物种利用,而另一些则被少数物种利用. 这项研究确定了针对微生物干预和共生设计的特定饮食化合物.
科学领域:
- 微生物组研究 微生物组研究
- 代谢网络分析代谢网络分析
- 系统生物学 系统生物学
背景情况:
- 人们认识到肠道微生物组在饮食反应和个性化营养中的作用.
- 对饮食化合物的微生物代谢缺乏全面的基因组基础的洞察力.
研究的目的:
- 用基因组规模的代谢网络来描述微生物-代谢物相互作用.
- 为了识别特定的饮食化合物,由有限的微生物物种代谢.
主要方法:
- 从注释的微生物基因组构建了代谢网络.
- 分析了微生物属和物种中代谢物和饮食化合物利用的变化.
- 利用纵向微生物组数据,将微生物丰度与代谢能力相关联.
- 开发了一种基于网络的方法来识别特定的饮食化合物.
主要成果:
- 微生物种的代谢物和食化合物处理能力的实质性变化 (四倍).
- 在同一个属的物种中观察到的高代谢相似性.
- 使用特定代谢物质的物种数量的显著变化 (1至818).
- 鉴定了特定于少量微生物物种的饮食化合物.
- 对具有相似代谢能力的微生物种群的丰富性观察到正相关性.
- 在肠道微生物组处理食化合物的能力方面表现出功能稳定性.
结论:
- 量化揭示了肠道微生物代谢中的大规模变异和冗余.
- 已确定与有限数量的微生物物种相关的饮食化合物.
- 为设计基于微生物组的干预措施和用于健康益处的共生菌提供了基础.
更多相关视频
相关概念视频
Dietary Connections
61.8K
In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...
61.8K
Genomics
40.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.6K
Molecules and Compounds
68.7K
Atoms and Molecules
68.7K
pH Scale
79.7K
Hydronium and hydroxide ions are present both in pure water and in all aqueous solutions, and their concentrations are inversely proportional as determined by the ion product of water (Kw). The concentrations of these ions in a solution are often critical determinants of the solution’s properties and the chemical behaviors of its other solutes. Two different solutions can differ in their hydronium or hydroxide ion concentrations by a million, billion, or even trillion times. A common means of...
79.7K
Solubility of Ionic Compounds
68.2K
Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.
68.2K
Proteins: Dietary Sources and Requirements
1.8K
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
1.8K


