帕金森病中的听力损失:系统性审查和元分析
Shahryar Rajai Firouzabadi1, Ida Mohammadi1, Hossein Golsorkh1
1School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
概括
听力损失在帕金森病 (PD) 中很常见,影响超过70%的人. 这一系统性审查强调了与PD相关的听力损失涉及外周和中央听力通路,这表明它可能是早期的非运动症状.
科学领域:
- 神经学 神经学
- 听力学 听力学是指听力学.
- 神经科学是一个神经科学.
背景情况:
- 听力损失是帕金森病 (PD) 的新出现的非运动症状.
- 患有PD (PwPD) 的人群中听力损失的患病率,特征和潜在机制需要进一步调查.
研究的目的:
- 系统地审查和评估PwPD中听力损失的患病率和特征.
- 综合使用纯音调听力测试,语音听力测试和中央听力处理测试的研究结果.
主要方法:
- 在PubMed,Embase和Web of Science数据库中进行了全面的搜索.
- 包括观察性研究,通过听力测量和中央听力处理测试评估PwPD患者的听力损失.
- 使用随机效应模型和元回归来分析聚合数据并检查异质性.
主要成果:
- 在1009名PwPD中,听力损失的综合流行率为73.9%,明显高于对照组 (OR=1.82).
- 高频听力损失比低频听力损失 (45.1%) 更普遍 (82.6%).
- 确定了中央听觉处理缺陷,包括脑干听觉唤起的潜能和像N200和P300这样的晚期皮质潜能的长时间延迟.
结论:
- 听力损失是PD中常见的疾病,超过了与年龄相关的变化.
- 研究结果表明,PD相关的听力损失涉及外周和中央听觉通路.
- 听力损失可能是早期的非运动症状,也是PD认知脆弱性的潜在指标.
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