评估4.5岁最佳神经发育结果的患病率在以前接受心室辅助设备支持的儿童中
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Updated: Feb 1, 2026

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In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
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Shannon Oliver1, Holger Buchholz2, Darren H Freed2
1Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Pediatric transplantation
|January 31, 2026
概括
大多数接受心室辅助装置 (VAD) 的孩子都能在童年中存活下来. 这项研究发现,在三分之一的儿科VAD接受者中,神经发育是最佳的,女性性别和更晚的植入日期是保护因素.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 神经发育儿科 神经发育儿科
- 医疗器械技术 医疗器械技术
背景情况:
- 心室辅助器件 (VAD) 越来越多地用于儿童,大多数人活到成年.
- 了解长期的神经发育结果对于这个不断增长的人口至关重要.
研究的目的:
- 为了检查在6岁之前植入VAD的儿童的神经发育轨迹.
- 为了确定与最佳与非最佳的神经发育结果相关的因素后VAD.
主要方法:
- 在74名在6岁之前植入VAD的儿童中进行了前性开始-队列研究.
- 在4.5-7岁之间进行的神经发育评估.
- 通过认知,视觉运动和适应性行为得分定义的最佳结果,缺乏特定的并发症;用于分析的Firth多重回归.
主要成果:
- 对于48名幸存者,可以进行神经发育评估.
- 在33%的患者中观察到最佳的神经发育结果.
- 2015-2020年间的女性性别 (OR 8.03) 和VAD植入物 (OR 6.59) 与最佳结果有关.
- 神经损伤 (VAD前/后) 与非最佳结果 (OR 0.10) 有关.
结论:
- 三分之一的儿科VAD接受者实现了最佳的神经发育结果.
- 女性的性别和最近的植入日期 (2015-2020年) 是保护因素.
- 神经损伤显著增加了非最佳神经发育结果的风险.
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