相关实验视频

Updated: Feb 1, 2026

Analysis of SNARE-mediated Membrane Fusion Using an Enzymatic Cell Fusion Assay
09:19

Analysis of SNARE-mediated Membrane Fusion Using an Enzymatic Cell Fusion Assay

Published on: October 19, 2012

14.5K

奇孔古尼亚病毒E1融合环膜相互作用:保存残留物和浅插入

Naresh Kumar Gudigamolla1, Birupaksha Das1, Preeti Pragya Panda1

  • 1School of Biological Sciences, National Institute of Science Education and Research, Bhubaneswar, An Off-Campus Center of Homi Bhabha National Institute PO Jatni, Khorda, Odisha 752050, INDIA.

Biophysical journal
|January 31, 2026
PubMed
概括

第二类病毒融合蛋白,如 chikungunya virus E1,通过保存的甘氨酸和酸残留物使用浅层膜插入来破坏脂质二层的稳定,并介导病毒的进入.

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SNAREs and Membrane Fusion01:43

SNAREs and Membrane Fusion

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Fusion of Secretory Vesicles with the Plasma Membrane

Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
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Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
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Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
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