一种双重纳米体工程乳制品衍生细胞外囊泡纳米药物,向瘤相关的巨细胞和癌细胞,用于癌症治疗
Zhiang Liu1,2, Ying Chen1,2, Yulin Cao1,2
1Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
Journal of extracellular vesicles
|January 31, 2026
概括
这项研究引入了一种新的双向纳米药物,该药物可将微RNA-21-5p抑制剂传递给癌细胞和瘤相关的巨细胞. 这种方法有效地抑制了瘤的生长,并重新编程了瘤的微环境,显示了癌症治疗的前景.
科学领域:
- 在瘤学瘤学.
- 纳米医学是一种纳米医学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 瘤进展涉及瘤微环境 (TME) 内的复杂相互作用.
- 针对单个细胞类型的向往往不足以消除癌症,需要多个向策略.
- 微RNA-21-5p,EGFR和PD-L1是瘤生长和免疫抑制的关键参与者.
研究的目的:
- 开发一种双重向的纳米药物,用于同时提供miR-21-5p抑制剂.
- 针对表达EGFR的瘤细胞和表达PD-L1的瘤相关巨细胞 (TAMs).
- 为了抑制瘤的进展,并重新编程免疫抑制TME.
主要方法:
- 开发了由牛奶衍生的工程外细胞囊泡 (mEVs),装饰着EGFR向 (7D12) 和PD-L1向 (KN035) 纳米体.
- 工程 EVs (7D12/KN035-iEVs) 用于提供 miR-21-5p 抑制剂.
- 双重向纳米药物的疗效在临床前癌症模型中进行了评估,包括免疫治疗和放射治疗的联合治疗.
主要成果:
- 7D12/KN035-iEVs成功地将miR-21-5p抑制剂传递给TME内的EGFR+和/或PD-L1+细胞.
- 双重向显著抑制了瘤生长,并重新编程了免疫抑制的TME.
- 这种纳米药物在与免疫疗法和放射疗法相结合时显示出协同效应.
结论:
- 开发的基于mEV的纳米医学是癌症治疗的有希望的通用策略.
- 该平台提供了一种多功能方法,用于针对TME的多个组件.
- 双重向纳米医学有可能提高癌症治疗结果,特别是在组合疗法中.
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