赞助偏见在随机对照试验在第三提取后的术后疼痛:一个元研究研究
Carlos Eduardo Dutra Rufato1, Mayara Colpo Prado1, Bernardo Antonio Agostini1
1Graduate Program in Dentistry, ATITUS Educação, Passo Fundo, Rio Grande do Sul, Brazil.
European journal of pain (London, England)
|January 31, 2026
概括
赞助并没有影响第三骨提取疼痛管理随机对照试验中的积极结果或选择性结果报告. 行业资助和非赞助的研究为临床决策提供了可比的证据.
科学领域:
- 药理学和麻醉学 药理学和麻醉学
- 临床试验方法论 临床试验方法论
- 基于证据的医学基于证据的医学.
背景情况:
- 研究药理干预措施,用于手术后的疼痛管理,在第三个提取后.
- 评估随机对照试验 (RCT) 中报告积极结果和选择性结果报告 (SOR) 的潜在偏见.
研究的目的:
- 评估赞助是否影响报告的积极结果和选择性结果报告 (SOR) 的发生在第三骨提取疼痛管理的RCT中.
主要方法:
- 对430个RCT进行了meta-research分析,比较了手术后疼痛的药理干预措施.
- 在PubMed,Scopus和Web of Science中进行的搜索;由两个独立审稿人进行的研究选择和数据提取.
- 通过将注册的协议与已公布的结果进行比较来评估SOR;使用奇平方测试分析赞助和报告之间的关联.
主要成果:
- 在赞助地位和选择性结果报告之间没有发现统计学意义上的关联 (p=0.861).
- 在赞助地位和报告积极结果之间没有发现统计学意义上的关联 (p=0.241).
结论:
- 赞助地位与选择性结果报告或在第三牙提取后手术后疼痛管理的RCT中报告积极结果的可能性没有关联.
- 行业资助和非赞助的研究提供了相对可靠的证据,支持在第三手术疼痛管理中公正的临床决定.
相关概念视频
01:54Molar Mass
86.7K
The identity of a substance is defined not only by the types of atoms or ions it contains but by the quantity of each type of atom or ion. For example, water, H2O, and hydrogen peroxide, H2O2, are alike in that their respective molecules are composed of hydrogen and oxygen atoms. However, because a hydrogen peroxide molecule contains two oxygen atoms, as opposed to the water molecule, which has only one, the two substances exhibit very different properties.
86.7K
01:29Bias in Epidemiological Studies
1.4K
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
1.4K
01:12Hindsight Biases
4.3K
Hindsight bias leads you to believe that the event you just experienced was predictable, even though it really wasn’t. In other words, you knew all along that things would turn out the way they did. Can you relate this to the phrase "Hindsight is 20/20" now?
4.3K
01:31Confirmation Biases
8.2K
The confirmation bias is the tendency to focus on information that confirms our existing beliefs and ignore information that is inconsistent with our expectations. For example, if you think that your professor is not very nice, you notice all of the instances of rude behavior exhibited by the professor while ignoring the countless pleasant interactions he is involved in on a daily basis. Have you ever fallen prey to the confirmation bias, either as the source or target of such bias?
8.2K
01:22Bias
7.4K
Bias refers to any tendency that prevents a question from being considered unprejudiced. In research, bias occurs when one outcome or answer is selected or encouraged over others in sampling or testing. Bias can occur during any research phase, including study design, data collection, analysis, and publication.
In statistics, a sampling bias is created when a sample is collected from a population, and some members of the population are not as likely to be chosen as others (remember, each member...
In statistics, a sampling bias is created when a sample is collected from a population, and some members of the population are not as likely to be chosen as others (remember, each member...
7.4K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
470
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
470