胎盘危机:破坏性选择和母体投资不足是哺乳动物胎盘进化和功能障碍的基础
Davis Laundon1,2, Neil J Gostling2,3, Ian G Reddin4,5
1School of Human Development and Health, Faculty of Medicine, IDS Building, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.
Biological reviews of the Cambridge Philosophical Society
|January 31, 2026
概括
祖先的哺乳动物胎盘效率不高,但由于母体投资低,导致"胎盘危机",推动了胎盘进化,可能是人类妊娠问题如子宫前症的基础.
科学领域:
- 进化生物学 进化生物学
- 生殖生物学 生殖生物学
- 哺乳动物生理学哺乳动物生理学
背景情况:
- 哺乳动物在活产和胎盘营养方面是独一无二的,尽管有共同的祖先,但表现出了显著的胎盘结构多样性.
- 以前对胎盘进化的研究集中在"效率范式"上,该范式无法解释观察到的多样性.
- 这项研究引入了一个新的范式来重新解释哺乳动物的胎盘进化.
研究的目的:
- 为了解哺乳动物的胎盘进化提出一个新的范式.
- 通过重新评估祖先的胎盘设计,挑战"效率范式".
- 探索母体投资和"胎盘危机"在胎盘进化中的作用.
主要方法:
- 胎盘结构的多维绘图.
- 哺乳动物母性投资的定量指标.
- 生理过程的计算建模.
主要成果:
- 祖先的哺乳动物胎盘的特点是母亲的投资较低,而不是高效率.
- 哺乳动物扩张到更大的利基创造了一个"胎盘危机"由于母体投资不足和妊娠功能障碍.
- 这种由选择和母胎冲突驱动的危机被认为是胎盘进化的基础.
结论:
- 祖先的胎盘的设计是一种特异性,可能会限制哺乳动物扩张到更大的身体中.
- 包括人类在内的一些灵长类动物目前可能正在经历'胎盘危机'.
- 孕产妇投资不足和不适当的胎盘被认为是人类妊娠障碍的进化基础,如子宫前.
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