在Zin/Chito-Oligosaccharide复合纳米颗粒中的阿斯丁封装:特征,稳定性,抗氧化效率和生物可访问性
Jian Ma1,2, Feihong Jia1,3,4, Jiangfeng Song1
1Institute of Agro-Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Journal of food science
|January 31, 2026
概括
谢因和基托-寡糖化合物纳米颗粒 (ZCNps) 增强了阿斯丁 (AST) 的输送. 这些ZCNps提高了AST的稳定性,生物可用性和抗氧化特性,用于食品应用.
科学领域:
- 食品科学 食品科学 食品科学
- 纳米技术纳米技术
- 生物化学 生物化学
背景情况:
- 阿斯塔丁 (AST) 具有显著的抗氧化和抗炎性质.
- 低水溶性和低生物可用性限制了AST的实际应用.
研究的目的:
- 开发一种高效的阿斯塔桑输送系统,使用和基托-寡糖化合物复合纳米粒子 (ZCNps).
- 提高AST在食品矩阵中的稳定性,生物可用性和功能性质.
主要方法:
- 使用抗溶剂沉来制造用于AST封装的ZCNps.
- 进行了结构特征,稳定性评估 (pH,盐,温度,储存) 和紫外线保护评估.
- 封装AST的抗氧化活性和生物可访问性与自由AST进行了比较.
主要成果:
- 装有AST的ZCNps (ZCANps) 实现了81.23%的封装效率和4.18 mg/g的药物负载,其COS比率为10:1.
- 在广泛的pH范围 (2-8),NaCl度 (高达50mmol/L),温度 (高达80°C) 和储存 (8周) 中,ZCNps表现出极好的稳定性.
- 与自由的AST相比,ZCANps为AST提供了62%的紫外线保护,并显示出显著增强的抗氧化活性和生物可访问性.
结论:
- ZCNps有效地封装阿斯塔山丁,提高其稳定性和生物可用性.
- 开发的ZCNps显示出作为一种交付系统来增强AST在食品应用中的功能性质的承诺.
- 这种纳米技术方法解决了阿斯塔克桑在食品工业更广泛使用方面的关键局限性.
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