基于CYP2C19基因型指导的质子抑制剂剂量:临床试验和现实世界的使用进展

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Updated: Feb 1, 2026

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Han Minh Thuy1,2, Mitsushige Sugimoto3, Pham Minh Ngoc Quang1,4

  • 1Department of Environmental and Preventive Medicine, Oita University, Yufu, Japan.

Expert review of clinical pharmacology
|January 31, 2026
PubMed
概括

基因型导向的质子抑制剂 (PPI) 疗法通过考虑单个细胞染色体P450 2C19 (CYP2C19) 遗传变异来优化与酸相关疾病的治疗,从而提高疗效和安全性.

关键词:
在CYP2C19中.胃食道逆流性疾病 (GERD) 是一种疾病.以基因型为指导的剂量定量在Helicobacter Pylori的研究中,质子抑制剂 (PPI) 是一种量身定制的治疗方法

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