在中度至重度的大动脉缩症中,生物年龄加速和全因死亡率:一项前性队列研究
Yiqi Zheng1, Xinghao Xu2, Zhenyu Xiong2
1Department of Cardiology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University), Guangzhou, China; Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
JACC. Asia
|January 31, 2026
概括
生物年龄加速 (BAA) 预测了中度至严重的大动脉狭窄 (AVS) 的死亡率. 较高的BAA表明风险增加,建议将其用作AVS患者的预后指标.
科学领域:
- 心脏病学 心脏病学
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 生物衰老加速 (BAA) 是一个新兴的衰老生物标志物.
- 它在中度至重度的大动脉狭窄症 (AVS) 的预后意义尚未得到充分确立.
研究的目的:
- 研究中度至重度AVS患者的BAA和全因死亡率之间的关联.
- 为了确定BAA是否可以作为这个患者队列的预后指标.
主要方法:
- 利用了ARISTOTLE研究中559名患者的数据.
- 使用KDM-BA和PhenoAge算法进行BAA评估.
- 采用了考克斯回归,限制立方线回归 (RCS) 和增量预测值分析.
主要成果:
- 在平均35.5个月的随访期间,发生了153例死亡.
- 在最高的BAA四分位数中观察到较高的死亡率 (日志排名P < 0.0001).
- 每个SD增加BAA独立预测更高的死亡率 (HR:1.35-1.36) 和改进的预测模型.
结论:
- 生物标志物衍生的BAA独立地与中度至重度AVS的全因死亡率增加有关.
- BAA显示出作为中度至重度AVS患者有价值的预后指标的潜力.
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