在患有1型糖尿病的儿童和青少年中,身体脂肪和血糖控制之间的关系
Claudio Maffeis1, Ilaria Fierri1, Elisa Morotti1
1Section of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology, University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale Stefani, 1, Verona, 37126, Italy.
Acta diabetologica
|January 31, 2026
概括
患有1型糖尿病 (T1D) 的儿童体内的多余脂肪与较差的血糖控制有关. 管理肥胖对于改善儿科T1D患者的健康结果至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 糖尿病研究研究 糖尿病研究
背景情况:
- 儿童群体的1型糖尿病 (T1D) 管理需要了解影响血糖控制的因素.
- 身体肥胖越来越被认为是导致青少年代谢失调的潜在因素.
- 通过血红蛋白A1c (HbA1c) 和时间范围 (TIR) 评估的血糖控制仍然是T1D护理的主要目标.
研究的目的:
- 检查诊断为T1D的儿童和青少年体脂肪和血糖控制指标之间的关联.
- 确定特定的脂肪指标,预测该人口中的血糖结果.
主要方法:
- 一项涉及364名年龄在6-18岁的T1D患者的横截面研究.
- 使用生物电阻分析评估人体指数 (BMI,WHtR) 和身体成分 (FMI).
- 通过HbA1c和葡萄糖传感器数据 (TIR) 评估血糖控制;使用斯皮尔曼相关和逻辑回归进行统计分析.
主要成果:
- 较高的脂肪度,包括脂肪质量指数 (FMI) 和腰比身高 (WHtR),与HbA1c升高和TIR降低相关.
- 后勤回归证实FMI和WHtR是实现目标HbA1c (<7.0%) 和TIR (>70%) 的重要独立预测因素.
- 这些关联无论每日胰岛素总剂量,性别或治疗方式如何,都保持显著.
结论:
- 增加的体脂肪率会对T1D的儿科患者的血糖控制产生负面影响.
- 肥胖症成为影响T1D儿童和青少年长期健康结果的关键,可修改因素.
- 管理肥胖的策略对于优化糖尿病护理和减轻该人口中的并发症至关重要.
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