西班牙多发性骨髓瘤的药理疗法的可用性
Gemma Garrido-Alejos1,2, Anna Feliu3,4,5, Daniel Gay-Pérez6
1Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, Barcelona, Spain.
概括
多发性骨髓瘤 (MM) 的药物治疗方案增加,转向组合和有条件批准. 虽然大多数在西班牙国家卫生系统 (NHS) 提供,但退款变得更加选择性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 多发性骨髓瘤 (MM) 治疗在过去二十年中发生了显著的进化.
- 治疗创新导致了MM的许多新药疗法.
研究的目的:
- 分析西班牙MM治疗药物治疗方案授权趋势.
- 评估西班牙国家卫生系统 (NHS) 中这些方案的可用性.
主要方法:
- 通过监管网站确定了在欧盟和/或西班牙 (2004-2024) 授权的MM药物方案.
- 分析了按方案组件,治疗线和批准频率的授权趋势.
- 从西班牙卫生部提取了报销数据.
主要成果:
- 批准了48个MM药物方案;40%是三胞胎,三分之二是复发/耐药性疾病.
- 批准从6 (2004-2009) 增加到18 (2020-2024),有条件授权的趋势 (2015-2024年53%).
- 退款从100% (2004-2014) 下降到61% (2015-2024),平均449天的时间到第一次决定.
结论:
- 欧盟和西班牙的MM药物批准数量有所增加,有利于组合疗法和有条件授权.
- 大多数已批准的MM治疗方法可以通过西班牙的NHS获得.
- 近年来,MM药物治疗方案的补偿变得更加有选择性.
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