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Updated: Feb 1, 2026

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
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Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

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在EGFR突变转移性转移性NSCLC的第一线和治疗序列:什么对哪个患者来说是正确的?

Pamela Abdayem1, Claudia Parisi1, David Planchard2,3

  • 1Département de médecine oncologique, Gustave Roussy, 114 Edouard Vaillant Street, 94805, Villejuif Cedex, France.

Drugs
|January 31, 2026
PubMed
概括

针对EGFR突变非小细胞肺癌 (NSCLC) 的第一线组合疗法在延缓抗性和大脑进展方面表现有前途. 用新型药物优化治疗序列是高级NSCLC患者的关键.

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Point mutations are genetic alterations involving the change of a single nucleotide base pair in DNA. Depending on how the alteration affects protein synthesis, they can lead to various consequences.Point mutations fall into the following types:Silent mutations occur when a nucleotide change does not alter the amino acid sequence due to the redundancy of the genetic code. For instance, changing ACC to ACA still encodes threonine, leaving the protein function unaffected. This occurs because...
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