系统性免疫炎症指数与骨关节炎风险之间的关联:一个横截面的NHANES 2013-2018研究
Hong Cheng1,2, Yue Qiu3,2, Wei Su4
1Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
Clinical rheumatology
|January 31, 2026
概括
系统性免疫炎症指数 (SII) 与骨关节炎 (OA) 的更高风险有关. 这一发现表明,SII可能有助于预测OA的发展和进展.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 骨关节炎 (OA) 是一个普遍的全球健康问题,特别影响老年人.
- 虽然其确切原因尚不清楚,但免疫和炎症过程被认为是OA发展的重要风险因素.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 与患骨关节炎 (OA) 的风险之间的关联.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (2013-2018) 中对15317名美国成年人的横截面分析.
- 通过SII测量的全身炎症状态是暴露变量,结果是OA.
- 用多重物流回归和分层分析来评估SII-OA关联,考虑复杂的调查设计和权重.
主要成果:
- 总共有15317名参与者被分析,其中2207人被诊断为OA.
- 与没有OA的参与者相比,OA的参与者表现出明显更高的SII水平.
- 逻辑SII与骨关节炎的患病率积极相关 (OR=1.27,P=0.0353),最高SII四分位数显示骨关节炎的患病率增加,而最低四分位数 (OR=1.18,P=0.0454).
结论:
- 这项研究表明,在美国大量成年人群中,SII升高和骨关节炎患病率增加之间存在显著的关联.
- 这种积极的关联在调整混因素和各种子组后仍然很强.
- SII成为OA潜在的预测生物标志物,为其诊断和管理提供了新的途径.
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