与Th17相关的基因PGAP1和TMBIM1作为系统性硬化症的潜在诊断和预测生物标志物:生物信息识别和小鼠模型验证

Qian Li1, Hanchao Li1, Bomiao Ju1

  • 1Department of Rheumatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.

Clinical rheumatology
|January 31, 2026
PubMed
概括

这项研究确定了PGAP1和TMBIM1作为关键基因,与系统性硬化症 (SSc) 中的T辅助器17 (Th17) 细胞有关. 这些基因显示出诊断和治疗SSc的潜力,并确定了特定的候选药物.

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