六轴机器人挤出混合水凝用于仿生气道模型制造
Jennifer O'Neil1, Larry A Villasmil-Urdaneta1, Perrin Woods1
1Department of Mechanical and Mechatronics Engineering Technology, Rochester Institute of Technology, Rochester, NY, USA.
Journal of biomaterials applications
|January 31, 2026
概括
研究人员使用新型机器人生物打印机和混合水凝开发了先进的3D打印气道模型. 这些模型准确地复制肺部几何和机械特性,以改善呼吸系统疾病研究.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 材料科学 材料科学 材料科学
背景情况:
- 呼吸道疾病是一个重大的全球健康挑战.
- 现有的3D肺部模型在解剖学准确性和机械性能方面扎.
研究的目的:
- 通过使用先进的生物打印来开发解剖学准确和机械兼容的气道模型.
- 探索混合水凝,以提高印刷保真度和结构完整性.
主要方法:
- 使用六轴机器人挤出生物打印机来制造气道结构.
- 采用酸 (A) 和碳氧甲基纤维素 (CMC) 的混合基,优化了A5C7混合物.
- 评估打印能力,结构稳定性和打印结构的机械性能.
主要成果:
- A5C7水凝混合物表现出优越的粘度,剪切稀释和扩散阻力.
- 成功打印了管状和分叉的气道结构,保留了光层几何.
- 打印模型表现出机械合规性,弹性回收和一致的孔真实性.
结论:
- 建立了一个概念验证机器人生物打印平台,用于创建现实的气道模型.
- 开发的混合液凝配方提高了打印保真度和模型稳定性.
- 这些先进的模型有可能用于未来的呼吸系统疾病研究和药物输送研究.
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