嗅觉丧失对患有鼻息肉的慢性鼻炎患者的重要性:管理和恢复的选择
Thomas S Higgins1,2, Jennifer E Douglas3, Robert C Kern4
1Kentuckiana ENT, A Division of ENT Care Centers, Louisville, Kentucky, USA.
Clinical and translational allergy
|January 31, 2026
概括
长期带鼻息肉的鼻鼻炎 (CRSwNP) 通常会导致嗅觉丧失. 像生物药物这样的治疗方法在恢复CRSwNP患者的嗅觉方面表现有希望.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 鼻科 鼻科是指鼻科的专家.
背景情况:
- 带鼻息肉的慢性鼻炎 (CRSwNP) 是一种常见的炎症状况.
- 嗅觉功能障碍是CRSwNP的主要症状,严重影响患者的生活质量.
- 机制包括多体的物理阻塞和影响嗅觉神经元的2型炎症.
研究的目的:
- 审查CRSwNP中嗅觉丧失的意义.
- 探索CRSwNP中嗅觉功能障碍的潜在机制.
- 评估CRSwNP中嗅觉恢复的当前和新兴治疗选择.
主要方法:
- 关于CRSwNP和嗅觉丧失的研究文献综述.
- 分析临床试验数据和治疗疗效的现实世界证据.
- 检查导致嗅觉障碍的机制.
主要成果:
- 嗅觉丧失是CRSwNP的主要负担,影响心理健康和安全.
- 皮质类固醇是最初的治疗方法,对于耐火病例来说,手术是另一种选择.
- 生物药物在手术后改善嗅觉方面表现出有效性.
结论:
- 气味丧失是CRSwNP的一个关键问题,需要有效管理.
- 了解机制是开发向治疗的关键.
- 共同决策对于选择治疗方法至关重要,以满足患者对气味恢复的目标.
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