治疗反应和亚托皮性皮肤炎不良结果的生物标志物:系统性审查
Eva Hilger1, Kaitlyn Chan1, Alphonsus Yip1
1Unit for Paediatric and Population-Based Dermatology Research, School of Basic and Medical Biosciences, St John's Institute of Dermatology, King's College London, London, UK.
概括
确定可靠的生物标志物对亚托皮性皮炎 (AD) 治疗反应和不良事件 (AE) 是至关重要的. 虽然升高的LDH可能预测dupilumab反应不佳,但IgE显示出预测dupilumab相关的眼睛表面疾病 (DAOSD) 的前景.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 药物基因组学 药物基因组学
背景情况:
- 亚托皮炎 (AD) 是一种普遍的慢性炎症性皮肤疾病,影响全球数百万人.
- 目前阿尔茨海默病的治疗选择正在扩大,需要精确的方法来预测患者的结果.
- 识别预测生物标志物是推动AD管理中个性化医学的关键.
研究的目的:
- 系统地审查和识别用于预测AD患者治疗反应的生物标志物.
- 在AD中识别与治疗相关不良事件 (AE) 相关的生物标志物.
- 评估生物标志物在指导全身疗法选择和管理方面的临床意义.
主要方法:
- 在Embase和MEDLINE进行了系统的文献搜索,直到2024年9月.
- 包括的研究包括随机对照试验,队列研究和病例控制研究.
- 提取和分析了与疾病进展和/或活动变化的生物标志物关联的数据.
主要成果:
- 28篇论文评估了治疗反应的生物标志物,11篇论文评估了AEs.
- 研究的生物标志物包括IgE,乙素,LDH,TARC,细胞因子,遗传变异和皮肤微生物组.
- 较高的LDH与较差的dupilumab反应相关,而IgE显示出预测dupilumab相关的眼睛表面疾病 (DAOSD) 的潜力.
结论:
- 预测治疗反应和识别患有AE风险的患者对于有效的AD管理至关重要.
- 阿尔茨海默病的临床异质性和多因素病因复杂化了生物标志物的发现.
- 合作研究举措对于推进精准医学和AD个性化护理至关重要.
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