40岁以上的成年人中炎症生物标志物和2型糖尿病之间的关联:一个横截面研究
1School of Public Health, Anhui Medical University, Hefei, Anhui Province 230032, 81 Meishan Road, China.
Neuro endocrinology letters
|January 31, 2026
概括
像TyG和AISI这样的新型炎症标志物与40岁以上中国成年人的2型糖尿病 (T2DM) 有关. 某些标志物的水平升高表明T2DM风险较高,表明它们对糖尿病评估的潜力.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 炎症反应与2型糖尿病 (T2DM) 病原发生有关.
- 传统的炎症标志物具有局限性;新型复合标志物的价值在中国成年人≥40.0中尚不清楚.
- 这项研究调查了这一群体中新型炎症标志物和T2DM之间的关联.
研究的目的:
- 评估九种新的炎症标志物与T2DM患病率之间的关系.
- 在中国成年人中评估PLR,LMR,AISI和TyG等标志物的诊断价值.
- 探索这些标记物在糖尿病风险评估中的潜在用途.
主要方法:
- 利用来自中国武汉市的194,348名参与者 (31,951名T2DM) 的数据.
- 从全血细胞计数中提取了9个炎症标志物.
- 使用多变量逻辑回归和子组分析来评估关联.
主要成果:
- 增加的MHR,NLR,SII,SIRI,AISI和TyG与T2DM有显著的相关性 (p < 0.001).
- PLR和PNR显示了反向关联 (p < 0.001).
- TyG和AISI的最高三位数显示T2DM的几率显著增加;PNR显示几率下降. 对年龄,性别,BMI和高血压观察到的效果修改.
结论:
- 流行T2DM与40岁以上的中国成年人炎症标志物升高有关.
- 这些易于获得的标记物可能有助于糖尿病风险评估.
- 一个横截面设计限制了炎症和T2DM发展之间的时间关系.
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