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机器学习模型用于快速预测和不确定性量化前列腺活检期间针曲的偏移
Nathan Hoffman1, Lidia Al-Zogbi2, Axel Krieger2
1Department of Mechanical Engineering, University of Maryland, College Park, Maryland, USA.
Medical physics
|January 31, 2026
概括
这项研究开发了一种快速,准确的针曲模型,用于跨关前列腺活检. 该模型与不确定性量化集成,使得更好的操作内规划和减少定位错误.
科学领域:
- 医疗工程 医疗工程
- 计算力学 计算力学 计算力学
- 手术规划 手术规划
背景情况:
- 跨关前列腺活检正在引起人们的兴趣,因为与跨直肠方法相比,感染风险降低了.
- 精确的针位置至关重要,但由于插入距离长,以及潜在的组织性质变化,在经皮膜活检中具有挑战性.
- 针曲的预测模型可以提高准准确度,减少手术尝试.
研究的目的:
- 开发一个计算效率高的模型,用于预测活检针曲,适用于手术内规划.
- 对实验数据验证预测模型.
- 将模型集成到蒙特卡洛不确定性量化框架中,以评估组织性质变化的影响.
主要方法:
- 使用基于机械的针曲模型来训练里埃特征神经网络 (FFNN).
- 基于机械的模型和FFNN都使用组织幽灵的实验数据进行了验证.
- 在蒙特卡洛模拟中使用FFNN模型来量化针曲的不确定性.
主要成果:
- 基于力学和FFNN模型都与实验结果有很好的一致性.
- 与基于机械的模型相比,FFNN模型实现了高精度,尖端屈曲误差约为0.3毫米.
- 一个低计算成本的蒙特卡洛不确定性量化模型 (约. 20 CPU 秒),显示了组织深度,硬度和不确定性对针曲的影响.
结论:
- 成功开发了一种计算效率高的蒙特卡洛不确定性量化模型,用于针曲.
- 这种方法显示出在前列腺活检中增强术内规划的巨大潜力.
- 该方法也适用于其他涉及柔性针的跨关节手术,如冷和支臂疗法.
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