作为癌细胞破坏的聚合物分子块,奇托-脱氧胆酸的相关pH响应性能
Watunyu Thanongsak1, Marie Kawahara2, Masahiko Nakamoto3
1Center of Excellence in Bioresources to Advanced Materials (B2A-CE), The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok, 10330, Thailand.
ChemMedChem
|January 31, 2026
概括
这项研究引入了用于癌症治疗的无药物分子块 (MB). 这些适应pH值的纳米粒子在酸性瘤环境中选择性地准和破坏癌细胞,在小鼠中显示出显著的瘤抑制.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 癌症治疗通常依赖于具有潜在副作用的药物.
- 开发无药物治疗策略是研究的一个关键领域.
- 聚合物纳米粒子为向药物输送和治疗提供了潜在的潜力.
研究的目的:
- 开发一种pH响应的聚合物分子块 (MB) 用于无药癌症治疗.
- 为了研究纳米粒子在不同pH值环境中的行为.
- 为了评估其 in vitro 和 in vivo 的疗效和生物相容性.
主要方法:
- 脱氧胆酸 (DCA) 与酸糖酸盐 (CS-S) 的结合,以创建CS-S-DCA纳米粒子.
- 在瘤相关的pH (6.2) 与生理pH (7.4) 之间的纳米粒子聚合的评估.
- 在癌症细胞系和正常纤维细胞的体外细胞毒性测定.
- 在小鼠模型中进行体内瘤抑制研究.
主要成果:
- CS-S-DCA纳米颗粒在pH 6.2时表现出pH触发的聚合,在pH 7.4时表现出稳定的分散.
- 对MiaPaCa-2,A-549和HT-29癌细胞观察到选择性细胞毒性.
- 正常的人体皮肤纤维细胞显示出良好的兼容性.
- 光成像证实了对癌细胞的偏好粘附.
- 在没有常规药物的情况下,在体内实现了显著的瘤抑制.
结论:
- 基于CS-S-DCA的pH响应的聚合物MB是一种有前途的无药癌症治疗策略.
- 这些纳米粒子表现出有针对性的聚合和选择性的癌细胞破坏.
- 这种方法为基于药物的癌症治疗提供了一个生物相容和有效的替代方案.
相关概念视频
Acid Strength and Molecular Structure
33.1K
Binary Acids and Bases
In the absence of any leveling effect, the acid strength of binary compounds of hydrogen with nonmetals (A) increases as the H-A bond strength decreases down a group in the periodic table. For group 17, the order of increasing acidity is HF < HCl < HBr < HI. Likewise, for group 16, the order of increasing acid strength is H2O < H2S < H2Se < H2Te. Across a row in the periodic table, the acid strength of binary hydrogen compounds increases with increasing...
In the absence of any leveling effect, the acid strength of binary compounds of hydrogen with nonmetals (A) increases as the H-A bond strength decreases down a group in the periodic table. For group 17, the order of increasing acidity is HF < HCl < HBr < HI. Likewise, for group 16, the order of increasing acid strength is H2O < H2S < H2Se < H2Te. Across a row in the periodic table, the acid strength of binary hydrogen compounds increases with increasing...
33.1K
Molecular Structure and Acidity
20.9K
An acid can be deprotonated to form a conjugate base or an anion. If the produced anion is more stable, then the acid is stronger. On the contrary, if the anion is unstable, then the acid is weaker. Hence, to determine the acidity of the compound, the stability of its conjugate base is studied using various factors.
The size effect explains the change in atomic size on acidity. When comparing the acids formed from elements that belong to the same column in the periodic table, their atomic sizes...
The size effect explains the change in atomic size on acidity. When comparing the acids formed from elements that belong to the same column in the periodic table, their atomic sizes...
20.9K
Actin Polymerization and Cell Motility
6.7K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
6.7K
Nucleic Acids
50.3K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
50.3K
Amino acids
105.4K
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
105.4K
Molecular Compounds: Formulas and Nomenclature
55.7K
Molecular compounds or covalent compounds result when atoms share electrons to form covalent bonds. Since there is no electron transfer, molecular compounds do not contain ions; instead, they consist of discrete, neutral molecules.
55.7K


