使用黑胡 (Piper nigrum) 种子提取物生物合成银纳米颗粒及其细胞毒性的评估
Nylton Ferreira Maciel1, Gleice VasconcelosPereira do Lago2, Glauce Vasconcelos da Silva Pereira2
1Programa De Pós-Graduação em Inovação Farmacêutica, Universidade Federal do Pará, Belém, Pará, Brazil.
Chemistry & biodiversity
|January 31, 2026
概括
使用Piper nigrum提取物与piperine (PPN) 功能化的银纳米粒子 (AgNPs) 的绿色合成显示了对胃癌细胞的增强细胞毒性作用. 这种环保的方法为癌症治疗提供了一个有前途的策略.
科学领域:
- 纳米技术纳米技术
- 绿色化学 绿色化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 传统的银纳米粒子 (AgNP) 合成依赖于有毒化学物质.
- 绿色合成利用天然来源,如植物提取物用于AgNP生产.
- 来自Piper nigrum的Piperine (PPN) 是一种具有潜在治疗应用的生物活性化合物.
研究的目的:
- 使用Piper nigrum种子提取物生物合成AgNP并分离皮佩林 (PPN).
- 将AgNP与PNP进行功能化,创建Np-AgPPN.
- 评估PPN和NP-AgPPN对胃癌细胞的细胞毒性.
主要方法:
- 使用Piper nigrum乙醇提取物的AgNPs的绿色合成.
- 使用UV-Vis,FTIR,SEM-EDS,XRD,TG和DSC进行合成纳米颗粒的表征.
- 在胃癌细胞的体外细胞毒性测定.
主要成果:
- 通过光谱和显微镜分析证实了AgNP与piperine的成功功能化.
- 与PPN相比,NP-AgPPN的结晶性和热稳定性发生了变化.
- 在实验室中,NP-AgPPN对胃癌细胞 (IC50 23.1-33.9 μg/mL) 显示出优异的抗瘤活性.
结论:
- 皮皮林功能化的AgNP (Np-AgPPN) 可以通过绿色化学方法有效合成.
- 与单独的piperine相比,NP-AgPPN对胃癌细胞表现出增强的细胞毒性作用.
- 这项研究强调了绿色合成的piperine功能化的AgNP在胃癌治疗中的治疗潜力.
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