由Ninjin'yoeito促进循环养,可以抵消老鼠的脆弱性
Lei Wang1, Yermek Rakhat2, Masanori Nakata3
1Division of Integrative Physiology, Kansai Electric Power Medical Research Institute, Osaka 553-0003, Japan; Department of Diabetes, Endocrinology and Metabolism, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan; Kobe Biotechnology Research and Human Resource Development Center, Kobe University Graduate School of Medicine, Kobe 650-0047, Japan; Division of Health Sciences, Medicine and Aging, Bin Zhou Polytechnic, Binzhou 256-603, China.
The journal of physiological sciences : JPS
|January 31, 2026
概括
忍者 忍者 忍者 忍者 忍者
科学领域:
- 老年学是一门学科.
- 时间生物学 时间生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 与衰老相关的脆弱性是一个重大的健康问题,通常与营养不良和饮食模式的破坏有关.
- 循环节律控制着食行为,在衰老和虚弱时观察到它们的失调.
- 草药Ninjin'yoeito (NYT) 在缓解虚弱症状方面表现有前途.
研究的目的:
- 为了研究忍者yoeito (NYT) 对昼夜养行为的影响.
- 为了探索"纽约时报"对老鼠心理和身体功能的影响.
- 为了确定NYT的治疗效果是否与在前活性阶段促进养有关.
主要方法:
- 给老年和年轻小鼠口服的Ninjin'yoeito (NYT),使用时间不同.
- 测量食物摄入量,重点关注18:00-20:00前活性阶段.
- 评估了调节食欲的荷尔蒙,神经,类似焦虑的行为,记忆力和握力.
- 在活动前阶段利用食物剥夺和双人养协议来验证发现.
主要成果:
- 宁津'yoeito (NYT) 增加了食物摄入量,特别是在18:00-20:00前活跃阶段,无论是老年小鼠还是年轻小鼠.
- 在活动前阶段,NYT调节食欲调节激素和神经.
- 在老年小鼠中,重复的纽约时报管理改善了抗焦虑行为,记忆力和握力.
- 当在预活性阶段限制养时,这些改善被取消了.
结论:
- 忍忍'yoeito (NYT) 促进了在前活性阶段的养,独立于给药时间.
- 用NYT准活动前期养可以改善与年龄相关的心理和身体功能下降.
- 在前活性期促进食代表了与衰老相关的脆弱性的一种新的治疗策略.
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