男性的乳腺健康和乳腺癌风险
Lakshmi Khatri1, Jessica Fraker2, Sandhya Pruthi3
1Breast Center, Integrated Surgical Institute, Cleveland Clinic, Cleveland, OH, USA.
Maturitas
|January 31, 2026
概括
本综述涵盖男性乳腺疾病,包括良性妇产不良和罕见的男性乳腺癌. 它强调BRCA2基因变异是关键的风险因素,并强调为男性量身定制的评估和管理.
科学领域:
- 医学科学 医学科学 医学科学
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 男性乳腺疾病虽然不常见,但在临床上具有意义.
- 了解像妇产不良这样的良性疾病对于诊断和管理至关重要.
- 男性乳腺癌虽然很少见 (<1%的乳腺癌),但具有显著的遗传和临床影响.
研究的目的:
- 审查有关男性乳腺疾病流行病学,解剖学,表现,诊断,管理和风险因素的现有证据.
- 整合影响男性乳腺的良性和恶性疾病的知识.
- 为了确定未来研究的知识差距.
主要方法:
- 对现有证据进行全面的文献审查.
- 对流行病学数据,临床表现和诊断方式的分析.
- 评估遗传风险因素和管理策略.
主要成果:
- 妇产不良需要了解荷尔蒙和药理学原因.
- 致病性BRCA2生殖系变异是男性乳腺癌的主要遗传风险因素 (~7%的终身风险).
- 男性的乳腺癌往往在晚年和年龄较大时出现,具有亚耳耳体质,乳头变化或疼痛.
结论:
- 针对性评估,风险评估和个性化护理对于患有乳腺疾病的男性至关重要.
- 对高风险男性的查建议受到稀缺数据的限制.
- 需要进一步的研究,以改善这种未被认可的人群的结果.
相关概念视频
Infertility in Males
569
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
569
Relative Risk
2.1K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.1K
The Y Chromosome Determines Maleness
8.2K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
8.2K
Disorders of the Male Reproductive System
5.1K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.1K
Factors Affecting the Risk of Infection
13.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.5K
Health Literacy
5.4K
Health literacy is an individual's or a community's capacity to comprehend, receive, read, and use relevant healthcare information and services. The World Health Organization (WHO, 2018) defines health literacy as the cognitive and social skills that determine the ability of individuals to gain access to, understand, and use information in ways that promote and maintain good health. As a result, the WHO helps individuals manage long-term health concerns, participate in preventative...
5.4K


