在牙周炎中吸烟和全身Th17/Treg免疫变化:一个横截面研究
Sangamithra Sidharthan1, Dharmarajan Gopalakrishnan2, Supriya Kheur3
1Department of Periodontology and Oral Implantology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant Tukaram Nagar, Pimpri, Pune, Maharashtra, India.
Archives of oral biology
|January 31, 2026
概括
吸烟在牙周炎中适度增加了全身Th17细胞,但牙中的局部免疫反应显示出微妙的变化. 需要进一步的研究才能充分理解这些免疫机制.
科学领域:
- 免疫学 免疫学 免疫学
- 牙周病学 牙周病学
- 口腔健康研究研究 口腔健康研究
背景情况:
- 牙周炎是一种常见的炎症性疾病,影响牙.
- 吸烟是牙周炎的已知危险因素,可以影响免疫反应.
- 在牙周炎中,T辅助细胞17 (Th17) 和调节性T细胞 (Treg) 的作用尚未完全理解,特别是关于吸烟的影响.
研究的目的:
- 研究吸烟如何影响患有牙周炎的个体的全身和局部免疫细胞群,特别是Th17和Treg细胞.
- 分析与Th17和Treg细胞相关的关键细胞因子在血液和牙组织中的表达.
- 为了确定吸烟是否在全身循环和局部口腔组织中不同地影响这些免疫标记物.
主要方法:
- 一项涉及45名参与者的研究分为健康的对照组,患有牙周炎的非吸烟者和患有牙周炎的吸烟者.
- 对所有参与者记录了临床牙周测量 (探针深度,附着损失).
- 使用流细胞计量来量化循环中的CD4+T细胞,Th17细胞和Treg细胞. 使用qRT-PCR分析了有关细胞因子 (IL-17A,FOXP3,IL-12(p35),hEBI3) 的基因表达.
主要成果:
- 与非吸烟者和健康对照人群相比,患有牙周炎的吸烟者患有牙周病明显恶化.
- 在两个牙周炎组中都观察到循环中的CD4+T细胞和Tregs水平升高,在吸烟者中发现的Th17频率最高.
- 尽管有系统性免疫变化,但牙周组织中关键细胞因子的基因表达在牙周炎组之间没有显著差异,这表明微妙的局部转录性改变.
结论:
- 牙周炎与全身免疫系统的显著变化有关,而牙的局部免疫变化不那么明显.
- 吸烟似乎适度提升了全身Th17反应,但并没有显著改变牙中的局部细胞因子表达.
- 需要进行更广泛的纵向研究,以充分阐明牙周炎所涉及的复杂免疫机制,特别是吸烟的影响.
相关概念视频
Cross-Sectional Research
12.5K
In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...
12.5K
Finding Volume Using Cross-Sectional Area
70
For solids whose cross-sectional areas vary in a predictable way, volume can be determined by integrating these areas along an axis perpendicular to the slices. This approach is particularly useful for polyhedral solids, where classical geometric formulas may not be immediately applicable. A tetrahedron provides a clear example of how cross-sectional integration can be applied to a three-dimensional object with continuously changing geometry.Consider a tetrahedron with height h and a base that...
70
Profile Leveling and Cross Sections
1.6K
Profile leveling and cross-sections are surveying methods used to determine and document terrain elevations for infrastructure projects such as highways, railroads, canals, and pipelines. These methods provide data for earthwork planning and alignment of proposed routes. Profile leveling involves measuring elevations along a fixed line to create a vertical terrain profile. A surveyor sets up a leveling instrument at the benchmark (BM) and records a backsight (BS) to determine the...
1.6K
Spinal Cord: Cross-sectional Anatomy
4.8K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
4.8K
Crossing Over
171.9K
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
171.9K
Alterations in Respiration II
1.8K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.8K


