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根据女消防员在训练中接触火灾的不同代谢概况
Tuo Liu1, James Hollister2, Krystal J Kern1
1Department of Community, Environment, and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
International journal of hygiene and environmental health
|January 31, 2026
概括
训练火灾暴露导致女性消防员发生显著的代谢变化,影响与氧化应激和细胞损伤相关的途径. 这些变化凸显了火灾事件后慢性炎症和疾病的潜在风险.
科学领域:
- 环境健康 环境健康
- 代谢学 代谢学 代谢学
- 职业健康 职业健康 职业健康
背景情况:
- 女消防员患癌症和生殖问题的风险更高.
- 这些风险背后的代谢途径尚不清楚.
研究的目的:
- 在女性消防员中确定与训练火灾暴露相关的尿液代谢物.
- 确定受这种暴露影响的代谢过程.
主要方法:
- 在训练前和训练后的尿样上,高分辨率的代谢量 (HRM).
- 统计分析确定了差异表达代谢物 (DEM).
- 代谢组丰富分析 (MSEA) 确定了丰富的代谢途径.
主要成果:
- 在四种HRM模式中识别了许多代谢物和DEM.
- 葡萄糖脂代谢得到了显著的丰富.
- 燃烧室/塔暴露导致比闪火灾更大的代谢变化.
结论:
- 训练火灾暴露导致女性消防员的广泛代谢变化.
- 这些变化涉及氧化应激和细胞损伤的途径.
- 研究结果表明,火灾暴露,炎症和疾病风险之间存在联系.
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