神经性厌食症中的结构性大脑变化:全球大脑体积和解剖学概率估计 (ALE) 的元分析与功能解码方法相结合
Lara Keller1, Leon D Lotter2, Claudia R Eickhoff3
1Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LVR University Hospital Essen, University of Duisburg-Essen, Wickenburgstr. 21, Essen 45147, Germany; Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital RWTH Aachen, Neuenhofer Weg 21, Aachen 52074, Germany; West German Center for Child and Adolescent Health, Partner Site Essen, Germany.
神经性厌食症 (AN) 中的大脑体积损失随着体重恢复而改善,但显示持续的灰质减少. 这一元分析澄清了AN患者和康复期间的大脑变化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 急性神经性厌食症 (AN) 与显著的大脑体积损失有关.
- 在康复期间这些大脑变化的长度结果仍然不清楚.
研究的目的:
- 进行全面的元分析,调查AN患者的全球和区域结构性大脑变化.
- 为了澄清恢复期间大脑结构变化的时间进程和残留效应.
主要方法:
- 从40篇论文 (N=1130名患者) 中提取了大脑体积得分和神经成像坐标,用于全球分析.
- 在35篇论文 (N=412个焦点) 的神经成像坐标上使用解剖概率估计 (ALE) 进行区域分析.
- 通过Neurosynth数据库进行空间定位分析.
主要成果:
- 全球灰质 (GM),白质 (WM) 和脑脊液 (CSF) 显著减少,急性AN增加,随着体重康复改善.
- 即使经过1.5年的恢复,也观察到持续的全球转基因体积减少.
- 发现了广泛的转基因减少和皮质稀薄,带带状回环,前中心回环和前状回环的持续变化.
- 与吃饭,食物,威胁和强化相关的大脑区域相对保留.
结论:
- 瘤包括显著的,部分可逆的全球和区域大脑结构变化.
- 剩余的大脑体积缺陷即使在重量恢复后仍然存在.
- 研究结果为AN病理生理学提供了洞察力,并可能为有针对性的治疗策略提供信息.
相关概念视频
Anorexia Nervosa
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Functional Brain Systems: Limbic System
Higher Mental Functions of the Brain: Language
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Higher Mental Functions of Brain: Learning and Memory
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
Functional Brain Systems: Reticular Formation
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...


