心脏生物标志物与一般人口的纵向认知变化相关联
Fang-Fei Wei1, Dubo Chen2, Chaoxin Xu3
1Department of Cardiology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; NHC Key Laboratory of Assisted Circulation and Vascular Diseases, Sun Yat-sen University, Guangzhou, Guangdong, China; Department of Cardiology, Huiya Hospital of the First Affiliated Hospital, Sun Yat-sen University, Huizhou, Guangdong, China.
The journal of prevention of Alzheimer's disease
|January 31, 2026
概括
心脏生物标志物,N-终端亲B型尿素 (NT-proBNP) 和高灵敏性心脏素T (hs-cTnT),与认知能力下降有关. 这些发现表明,心脏健康可能在维持认知功能方面发挥作用.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 老年学是指老年学的学科.
背景情况:
- 心脏生物标志物与长期认知变化之间的关系尚不清楚.
- 高灵敏性心脏托洛T (hs-cTnT) 和N终端亲B型尿素 (NT-proBNP) 是关键的心脏生物标志物.
研究的目的:
- 调查心脏生物标志物与随时间变化的认知表现之间的关联.
- 探索NT-proBNP和hs-cTnT水平如何与认知能力下降有关.
主要方法:
- 社区动脉样硬化风险研究包括2540名没有中风的参与者 (平均年龄为74.5岁).
- 分析了微型精神状态检查 (MMSE) 成绩的变化,与基线NT-proBNP和hs-cTnT水平相关.
- 用多变量线性和受限立方线回归模型来评估关联.
主要成果:
- 在6.6年内,MMSE得分下降,低MMSE得分的患病率增加.
- 无论是NT-proBNP还是hs-cTnT都与绝对MMSE得分变化有线相关.
- 在黑人,老年参与者中,对NT-proBNP在糖尿病患者中,对hs-cTnT在正常压力患者中,相关性更强.
结论:
- NT-proBNP和hs-cTnT与认知表现的变化有关.
- 虽然并没有证明因果关系,但针对心脏健康可能是缓解认知衰退的策略.
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