在大鼠中使用经过验证的UPLC-MS/MS方法对α,ω-dipropionic酸聚乙烯甘醇 (PA-PEG12-PA) 的综合药理动力学和组织分布研究

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Meichen Liu1, Yalin Yu2, Yifei Jing2

  • 1Department of Nephrology, Central Hospital of Dalian University of Technology, Dalian University of Technology, Dalian 116000, PR China; School of Chemical Engineering, Ocean and Life Sciences, Dalian University of Technology, Panjin 124221, PR China.

Journal of pharmaceutical and biomedical analysis
|January 31, 2026
PubMed
概括

这项研究描述了大鼠中α,ω-二烯酸聚乙烯甘醇 (PA-PEG-PA) 的药理动力学. 研究结果显示,脏清除速度快,脏积累量显著,为PEGylated药物递送系统提供了洞察力.

关键词:
排泄 排泄 排泄药物动力学研究 药物动力学研究聚乙烯糖醇是一种聚乙烯基醇.组织分布 组织分布在 UPLC-MS/MS 中使用.

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