绘制平地以外的酶链结合化学型的不断变化的景观:对富含sp3结合剂的系统分析和机会

Shangde Liu1, Tianlei Han1, Zhenyu Zhang1

  • 1Central Hospital of Dalian University of Technology, Dalian, Liaoning 116033, China; School of Pharmacy, Faculty of Medicine, Dalian University of Technology, Dalian, Liaoning 116024, China.

概括

发现新的激酶抑制剂对于向治疗至关重要. 这项研究分析了4370个激酶-连接体复合体,揭示了当前链结合动机的局限性,并突出了新型ATP竞争性激酶抑制剂设计的机会.

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