乐观主义训练对冠状动脉疾病动脉硬化生物标志物的影响:一项随机对照试验
Masoumeh Sadeghi1, Nasim Kakavand1, Mohammadesmaeil Aramesh Boroujeni2
1Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Journal of psychosomatic research
|January 31, 2026
概括
乐观主义训练改善了心脏病患者的心理健康,但对ICAM-1和VCAM-1等粘附分子的影响很小,不确定. 需要进行更大规模的研究来确认临床意义.
科学领域:
- 心血管医学 心血管医学
- 心理神经免疫学 心理神经免疫学
- 生物标志物研究 生物标志物研究
背景情况:
- 动脉样硬化是一种慢性炎症性疾病,导致心血管疾病 (CVD) 的死亡率.
- 细胞间粘附分子-1 (ICAM-1) 和血管细胞粘附分子-1 (VCAM-1) 是动脉样硬化发展的关键.
- 乐观主义干预对这些粘附分子的影响尚不清楚.
研究的目的:
- 研究基于乐观的干预对冠状动脉疾病 (CAD) 患者的ICAM-1和VCM-1水平的影响.
- 评估干预后的心理变化,包括抑郁,焦虑和负面影响.
主要方法:
- 一项随机对照试验,包括61名心脏病康复后心脏病患者.
- 一个为期八周的基于小组的乐观训练计划与注意力匹配的对照组相比.
- 在基线和16周通过ELISA测量血ICAM-1和VCAM-1;心理评估.
主要成果:
- 乐观主义干预显著减少了抑郁,焦虑和负面影响 (p < 0.05).
- 干预后观察到粘附分子水平的小,不确定的群体间差异.
- 没有显著的分组时间相互作用或乐观主义变化和粘附分子水平之间的相关性.
结论:
- 乐观主义干预为CAD患者提供心理上的好处.
- 在粘附分子生物标记物 (ICAM-1,VCAM-1) 中观察到的变化很小,不确定.
- 需要进一步研究更大的样本大小,以澄清这些发现的临床相关性,因为生物标志物的高变异性.
相关概念视频
01:30Coronary Artery Disease I: Introduction
1.1K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.1K
01:26Coronary Artery Disease II: Pathophysiology
455
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
455
01:27Coronary Artery Disease V: Interprofessional Care
270
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
270
01:30Coronary Artery Disease III: Clinical Manifestations
374
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
374
01:26Coronary Artery Disease IV: Preventive Measures
689
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
689
01:30Peripheral Artery Disease I: Introduction
380
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
380