认知控制网络的全球功能连接性预测了老年人的任务交换性能
Bryan Madero1, Matthew Sodoma1, Chris Oehler1
1Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, 52242, USA.
概括
年龄较大的成年人.
科学领域:
- 神经科学是一个神经科学.
- 认知老龄化 认知老龄化
- 执行职能 执行职能 执行职能
背景情况:
- 衰老与执行功能 (EF) 的下降和大脑网络连接的改变有关.
- 对于任务交换至关重要的认知灵活性得到了认知控制网络 (CCN) 的支持.
- 老年人中CCN全球功能连接 (GFC) 和任务交换之间的关系尚不清楚.
研究的目的:
- 调查CCN GFC与老年人任务交换性能之间的关联.
- 检查不同大脑网络如何与任务切换的特定方面相关 (混合成本和切换成本).
主要方法:
- 年长的成年人 (55-80岁) 进行了两种任务交换版本 (单独和重叠).
- 静止状态fMRI数据被收集用于计算整个灰质GFC.
- 为CCN,默认模式网络 (DMN) 和体力运动网络 (SMN) 提取了GFC.
主要成果:
- 年长的成年人在重叠任务版本中表现较差.
- 在CCN,DMN和SMN中增加的GFC与在重叠版本中降低的混合成本相关.
- 索马托摩托网络GFC与混合成本增加和单独版本的切换成本降低有关.
结论:
- 通过GFC表示,在CCN,DMN和SMN内进行更大的集成与增强的任务切换性能有关,特别是在工作内存负载高的情况下.
- 大脑网络连接在衰老期间保持认知灵活性方面发挥着重要作用.
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