局部控制与适度低分量的确定的放射治疗,同时提供与非极端软组织和骨肉瘤的同时整合增强技术
J D Towler1, C David1, O Willis1
1The London Sarcoma Service, University College Hospital, 235 Euston Road, London, NW1 2BU, UK.
Clinical oncology (Royal College of Radiologists (Great Britain))
|January 31, 2026
概括
适度低分量的终极放射疗法 (MHDRT) 为不可手术的非四肢肉瘤提供了有效的治疗选择. 这种方法在不适合或拒绝手术的患者中显示出具有可接受毒性的有希望的局部控制率.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 手术瘤学手术瘤学
背景情况:
- 手术是软组织肉瘤 (STS) 和骨肉瘤的主要治疗方法.
- 有相当数量的非四肢瘤患者不是切除的候选人.
- 对于这些病例的终极放射治疗,存在有限的结果数据,特别是危险器官附近的低分离.
研究的目的:
- 评估对中度低分量的终极放射治疗 (MHDRT) 的机构经验.
- 评估MHDRT在患有不可手术的非四肢STS和骨肉瘤的患者中的疗效和毒性.
- 在不适合或拒绝接受手术的患者中调查MHDRT.
主要方法:
- 在2021年7月至2024年9月期间,59名成年肉瘤患者接受了MHDRT.
- 治疗包括使用光子或质子疗法的60个疗程,分为28个部分.
- 剂量水平包括50.4 Gy和STS的63 Gy的同时综合增强 (SIB) 或骨肉瘤的70 Gy.
主要成果:
- 在1年的随访 (中位数为17.7个月) 时,局部控制为STS的90.8%,瘤的100%,高级骨肉瘤的55.6%.
- 在8.3%和10%的患者中,分别观察到急性和晚期3级毒性.
- 在瘤类型中实现了令人鼓舞的早期局部控制率.
结论:
- MHDRT是一种可行的激进治疗选择,用于不可手术的非四肢肉瘤.
- 在这个患者队列中,治疗表明可接受的毒性概况.
- MHDRT提供了令人鼓舞的早期本地控制,解决了对替代疗法的关键需求.
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