支气管镜术后的唾液培养改善了非结核性菌根性肺病的检测:一项回顾性研究
Kohei Yamamoto1, Tatsuya Imabayashi1, Toshiyuki Tanaka1
1Department of Respiratory Medicine, Japanese Red Cross Kyoto Daiichi Hospital, 15-749, Honmachi, Higashiyama-ku, Kyoto, 605-0981, Japan.
Respiratory investigation
|January 31, 2026
概括
收集支气管检查后的唾液 (PBS) 适度增加了非结核性菌根性肺病 (NTM-PD) 的诊断产量. 这种简单的策略增强了培养的积极性,类似于结核病诊断,患者负担最小.
科学领域:
- 肺部病理学 肺部病理学
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 支气管镜术后唾液 (PBS) 的诊断产量已被确立为结核病,但对非结核性菌根性肺病 (NTM-PD) 有限.
- 有效的NTM-PD诊断对于适当的治疗和患者管理至关重要.
研究的目的:
- 调查疑似NTM-PD的支气管镜中添加PBS的增量诊断收益率.
- 将支气管镜样本的培养阳性与PBS进行比较.
主要方法:
- 对220名怀疑NTM-PD的成年患者进行了逆向分析,这些患者接受了支气管检查.
- 从支气管洗/支气管膜洗和PBS在24小时内收集的培养结果的比较.
- 评估PBS提供的额外收益率.
主要成果:
- 从32.3%的支气管镜样本中培养了NTM.
- 在32.7%的病例中,PBS培养物呈阳性,明显高于支气管镜前吐 (17.3%).
- 结合两种样本类型,整体培养阳性增加到40.5%,其中PBS在8.2%的病例中是唯一的阳性来源.
结论:
- 将PBS添加到支气管镜检查中,为NTM-PD的诊断产量提供了适度但临床显著的增加.
- 这种策略很简单,负担很小,并且在没有额外的侵入性手术的情况下增强了诊断信息.
- 这些发现表明PBS是NTM-PD诊断的宝贵辅助,反映了它在结核病中的实用性.
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