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通过智能可切换纳米平台调节HIF-2α稳定,用于瘤免疫重编程和增强疗法

Zelun Li1, Guanhua Qiu1, Wenwen Guo2

  • 1Department of Hepatobiliary Surgery, Department of Medical Ultrasound, Guangxi Medical University Cancer Hospital, Guangxi Medical University, No. 71 Hedi Road, Nanning, 530021, Guangxi, China.

Biomaterials
|January 31, 2026
PubMed
概括

这项研究引入了一种新的纳米平台,通过提供氧气并触发细胞死亡来对抗瘤中的慢性缺氧. 这种方法提高了癌症治疗的有效性,并增强了抗瘤免疫反应,将"冷瘤"转化为"热瘤".

关键词:
这就是HIF-2α.氧气过低是因为缺氧.免疫原性细胞死亡反应性氧物种 (ROS) 是一种反应性氧物种.声动力学疗法 声动力学疗法瘤微环境是一个微环境.

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