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Updated: Feb 2, 2026

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds

Published on: August 8, 2025

由Chromobacterium haemolyticum引起的污水冲击在中国最初被误认为是C. violaceum之后

Huiying Ye¹, Yanhong Wu¹, Xiaohong Xu¹

¹Department of Clinical Laboratory, Sanmen People's Hospital, Taizhou, Zhejiang, China.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

|January 31, 2026

概括

由Chromobacterium haemolyticum引起的罕见血流感染发生在一个老年人暴露在田水后. 准确的鉴定和抗菌素敏感性测试对于控制这种多药耐药性病原体至关重要.

科学领域:

临床微生物学临床微生物学
传染性疾病传染性疾病
基因组学就是基因组学.

背景情况:

染色菌种可以引起严重的感染.
准确的物种级别识别对于适当的治疗至关重要.
染色菌血解菌是一种罕见但潜在的重大病原体.

研究的目的:

报告一种由Chromobacterium haemolyticum引起的血液感染病例.
为了突出Chromobacterium在物种级别识别方面的挑战.
描述一种C.haemolyticum分离物的抗菌素耐药性概况和遗传基础.

主要方法:

一个80岁的男性患有败血症的案例介绍.
使用MALDI-TOF的初始识别MS.
通过全基因组测序 (WGS) 进行最终识别和抵抗基因检测.
抗微生物敏感性测试 (AST).

主要成果:

患者在接触污染水后出现了严重的软组织感染和败血症休克.
马尔迪-托夫MS建议C.violaceum,但表型特征 (缺乏violacein,存在β-hemolysis) 表示错误识别.
世界地质系统证实了这种分离物是Chromobacterium haemolyticum.
该分离物对由blaCRH-1基因介导的β-乳酸抗生素,包括卡巴胺,表现出高水平的耐药性.
观察到对诺基诺和四环素的敏感性.

结论:

精确的物种级别的Chromobacterium鉴定是必不可少的,因为表型特征可能具有误导性.
全基因组测序是确定和理解耐药机制的宝贵工具.
染色菌血解菌可以导致严重的侵入性疾病,并表现出多种药物耐药性,需要仔细的抗菌感应性测试.
提高对C. haemolyticum的临床认识对于及时有效地管理感染很重要.

关键词:

抗微生物耐药性抗微生物耐药性细菌病是什么意思细菌病是什么意思这是一种Chromobacterium haemolyticum.这是一种Chromobacterium violaceum的细菌.整个基因组测序的测序 bla (((CRH-1) 是一个字.

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