两例快速进展的B型流感和黄金杆菌肺炎病例集群,死亡1例
Caopei Zheng1, Yulin Zhang2, Yu Wang3
1Department of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China.
概括
具有Panton-Valentine leucocidin (PVL) 阳性的金黄色葡萄球菌和流感病毒的同时感染可能导致严重的肺炎. 基因组测序在两名建筑工人中帮助诊断和治疗.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 肺部病理学 肺部病理学
背景情况:
- 潘顿-瓦伦丁白素 (PVL) 阳性甲素敏感金黄色葡萄球菌 (MSSA) 与流感病毒的同时感染可能导致严重的死性肺炎.
- 一组由两名流行病学相关的建筑工人组成的集群,在共同的职业暴露后出现了严重的肺炎.
研究的目的:
- 为了说明PVL阳性MSSA和流感病毒之间的危及生命的协同作用.
- 突出重症,耐火性肺炎病例中甲基因组下一代测序 (mNGS) 的诊断实用性.
- 在高风险的职业环境中强调呼吸道保护的重要性.
主要方法:
- 两名建筑工人患有严重肺炎的案例报告.
- 诊断评估包括常规方法和呼吸道样本 (唾液和支气管洗液) 的下一代元基因组测序 (mNGS).
- 临床管理和结果评估.
主要成果:
- 一名患者死于快速进展的肺炎,而另一个患者在重症监护后幸存下来.
- 传统的诊断方法是不够的.
- 在幸存的患者中,mNGS确定了与PVL阳性ST22MSSA和流感B病毒 (IBV) 的同时感染.
- 以mNGS结果为指导的向治疗导致了成功的治疗.
结论:
- 具有PVL阳性的MSSA-流感共感染表现出极端的毒性.
- mNGS是诊断严重,不耐治疗的肺炎的一个有价值的工具.
- 在职业环境中,有效的呼吸道保护对于潜在的感染病原体暴露至关重要.
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