第一个报告的Capnocytophaga cynodegmi感染性内心炎病例:一个诊断奥德赛
Lucy Ngoc B Tran1, Ran Zhuo2, Meher Singha1
1Division of Infectious Diseases, UCLA David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
概括
本案例报告详细介绍了第一个由Capnocytophaga cynodegmi引起的传染性内心炎的病例,这是一种罕见的口腔细菌. 先进的测序证实了病原体,突出了它对人类严重感染的潜力.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 心脏病学 心脏病学
背景情况:
- 动物口腔植物中的一个开始者Capnocytophaga cynodegmi很少引起人类感染,通常是局部软组织问题.
- 感染性内心炎 (IE) 是心脏门的严重感染,通常是由常见的细菌引起的.
- 双主动脉和酒精使用障碍是已知的心血管并发症的危险因素.
研究的目的:
- 报告第一个由Capnocytophaga cynodegmi引起的感染性内心炎病例.
- 突出IE中与苛刻的病原体相关的诊断挑战.
- 强调先进分子诊断在培养负IE病例中的实用性.
主要方法:
- 一个39岁的男性患有败血症并怀疑IE的案例介绍.
- 最初的诊断包括血液和门培养,结果是阴性.
- 进行了血的元基因组测序和扩张组织的目标下一代测序 (NGS).
主要成果:
- 尽管有负面的培养,但元基因组测序最初建议Capnocytophaga canimorsus.
- 门组织的向NGS最终确定了Capnocytophaga cynodegmi.
- 患者在门置换和用安培-苏尔巴克坦的抗生素治疗后康复.
结论:
- 卡普诺细胞虫 (Capnocytophaga cynodegmi) 可以导致严重的,危及生命的传染性内心炎.
- 像NGS这样的先进分子技术对于诊断易致性或难以培养的生物体引起的IE至关重要.
- 临床医生应考虑在培养负IE中的动物性传染性Capnocytophaga物种,特别是在风险个人中.
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