在非痴呆症参与者中,认知训练引起的形态和微观结构性大脑变化:系统性审查和元分析
Eszter Radics1, Tímea Lázár1, Marah Qussous2
1Neurocognitive Research Centre, Nyírő Gyula National Institute of Psychiatry and Addictology, 1135 Budapest, Hungary; Centre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.
NeuroImage
|January 31, 2026
概括
在没有痴呆症的成年人中,认知训练没有显著改变大脑结构或生理学. 目前关于客观生物标志物的证据不足以推认知训练作为认知衰退的预防策略.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 生物标志物 生物标志物
背景情况:
- 对于认知衰退,建议进行认知训练,但其对客观生物标志物的影响尚不清楚.
- 这项研究调查了认知训练如何影响大脑结构和生理学.
研究的目的:
- 澄清认知训练对认知障碍客观生物标志物的影响.
- 评估认知训练后大脑结构和生理学的变化.
主要方法:
- 在MEDLINE,Embase和CENTRAL数据库中进行系统的文献搜索 (2023年11月).
- 包括的研究评估了在非痴呆症成年人的客观参数上的认知训练有效性.
- 随机效应模型用于计算平均差异 (MD) 和标准化平均差异 (SMD).
主要成果:
- 八个符合条件的物品被纳入定量分析;对PET,fMRI或液体生物标志物的数据不足.
- 没有观察到分数异构 (MD=0.01) 或海马体积 (SMD=0.03) 的显著差异.
- 在所有分析中都注意到了高度的异质性.
结论:
- 与对照组相比,认知训练没有显示出显著的形态或微观结构大脑变化.
- 目前,客观标记数据不支持认知训练作为认知衰退的预防方法.
- 未来的研究需要改进随机化,基线控制和标准化的方法.
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