在癌症幸存者中体外受精后的出生结果
Jama Brookes1, Alexis C Wardell2, Chelsea Anderson3
1Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC.
Fertility and sterility
|January 31, 2026
概括
与其他体外受精患者相比,接受体外受精 (IVF) 的癌症患者对大多数不良分娩结果的风险类似. 这些发现支持使用现有的试管婴儿数据为癌症患者提供有关怀孕结果的咨询.
科学领域:
- 生殖医学 生殖医学
- 在瘤学瘤学.
- 周围生理学 周围生理学
背景情况:
- 通过卵细胞检索来保护生育能力对于希望未来生育孩子的癌症患者至关重要.
- 了解癌症患者体外受精后的分娩结果对于明智的决策和咨询至关重要.
研究的目的:
- 为了比较癌症患者在IVF治疗前或之后接受卵细胞检索的癌症患者的不良分娩结果,与非癌症IVF患者相比.
- 评估妊娠高血压,低出生体重,早产,妊娠年龄小/大以及剖腹产的风险.
主要方法:
- 在美国九个州从2004年至2018年单个体试管婴儿分娩的回顾性队列研究.
- 包括有癌症史和没有癌症史的妇女,在癌症治疗之前或之后检索卵细胞.
- 使用多变量相对风险对结果进行比较,并根据人口和试管婴儿相关因素进行调整.
主要成果:
- 在135,274例试管婴儿分娩中,648例涉及癌症患者.
- 生育保存组显示出类似的早产,低出生体重和妊娠年龄小/大,但与非癌症组相比,剖腹产的发育率更高.
- 癌症治疗后的试管婴儿在大多数不良结果中没有明显的差异,但与特定的非癌症迹象相比,对于妊娠年龄来说,大癌症的风险较低.
结论:
- 接受试管婴儿治疗的癌症患者对大多数不良分娩结果的风险与非癌症患者的风险相似,除了潜在的较低风险.
- 这些发现表明,非癌症试管婴儿环境中的证据可以用于为癌症患者和癌症幸存者提供有关分娩结果的咨询.
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