暴露于,和和中风后的长期死亡率:一个队列研究
Yanling Gao1, Zhonghui Lin2, Qingyue Dai3
1Department of Neurological Rehabilitation, Rehabilitation Hospital affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province 350003, China; Fujian Key Laboratory of Rehabilitation Technology, Fuzhou, Fujian Province 350003, China.
概括
血液中的和含量增加,增加了中风幸存者的死亡风险. 然而,水银似乎在这个人群中提供了对某些死亡原因的保护作用.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管流行病学心血管流行病学
背景情况:
- 众所周知,重金属如,和对神经有毒作用.
- 这些金属与中风幸存者的死亡率之间的关联尚未得到充分理解.
研究的目的:
- 为了研究血中金属度与中风幸存者的死亡风险之间的关系.
- 为了确定,和是否对中风后所有原因和特定原因死亡率产生影响.
主要方法:
- 利用了来自国家健康和营养检查调查 (NHANES) 和国家死亡指数 (NDI) (1999-2018) 的数据.
- 在765名中风幸存者的血液中分析了金属水平 (,,),使用ICP-MS.
- 使用Cox的比例危险模型,对共变量进行调整,以评估死亡率关联.
主要成果:
- 较高的含量与所有原因死亡率的增加显著相关 (HR 2.02).
- 在最高四分位数 (HR 1.63) 中,含量增加与全因死亡率有显著的关联.
- 对所有原因 (HR 0.54) 和恶性瘤死亡率 (HR 0.08) 产生保护作用.
结论:
- 血中含量升高是中风幸存者因各种原因死亡的独立危险因素.
- 与所有原因死亡率的增加有着适度的关联.
- 可能对中风幸存者的死亡结果产生保护作用,需要进一步调查.
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