甲基醇与大脑小血管疾病和认知功能之间的关联 - 马斯特里赫特研究
Eline Berends1, Simone J P M Eussen2, Walter H Backes3
1Department of Internal Medicine, Maastricht University, Netherlands.; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Netherlands.
概括
血中介甲基醇 (MGO) 水平与更高的缺口性心脏病发作的可能性有关,这是大脑小血管疾病 (CSVD) 的标志物. 需要进一步的研究来确认MGO是否因果影响内心形成.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
背景情况:
- 大脑小血管疾病 (CSVD) 和痴呆的患病率随着年龄的增长而增加.
- 糖尿病是CSVD和认知衰退的关键风险因素,但机制尚不清楚.
- 甲基醇 (MGO) 是一种与糖尿病相关的代谢物,与微血管损伤有关.
研究的目的:
- 调查血MGO水平与MRI评估的CSVD标记物之间的关联.
- 为了检查血MGO和基于人口的队列认知功能之间的关系.
主要方法:
- 来自马斯特里赫特研究 (n=2515) 的横截面数据的分析.
- 血MGO通过UPLC-MS/MS进行测量.
- 通过MRI (n=1789) 评估的CSVD标志物 (白质强度过高,缺口性心脏病发作,微型血液)
- 调整为混因素的回归分析.
主要成果:
- 血MGO和CSVD标志物或认知功能之间没有线性关联.
- 与最低水平相比,中等血MGO水平显示内脏病发作的几率增加 (OR:2.26).
- 最高的血MGO度没有显示出与缺口性心脏病发作有显著的关联.
结论:
- 中间血MGO水平与较高的内心发作患病率有关.
- 需要进一步调查MGO在缺口性心脏病发作的因果作用.
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