埃莫丁:其作用在很大程度上是由于hormesis
Edward J Calabrese1, Peter Pressman2, A Wallace Hayes3
1School of Public Health and Health Sciences, Department of Environmental Health Sciences, Morrill I-N344, University of Massachusetts, Amherst MA 01003 USA.
概括
在各种生物模型中,埃莫丁表现出抑制作用,在低剂量时显示有益影响,在高剂量时显示有毒作用. 在细胞和动物研究中观察到的这种双相反应涉及激活关键的细胞适应路径.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 生物医学科学 生物医学科学
背景情况:
- 荷尔梅斯,双相剂量反应,在生物系统中越来越被认可.
- 埃莫丁是一种天然化合物,已表现出多种生物活性.
- 了解埃莫丁的抑制作用对于其治疗和毒理学评估至关重要.
研究的目的:
- 进行第一个综合性评估,以埃莫丁诱导的 hormetic-biphasic剂量反应.
- 分析研究设计,剂量-反应特征和emodin hormesis的机制基础.
- 评估 emodin 在生物模型和组织层面上对 hormetic 效应的普遍性.
主要方法:
- 关于以莫丁诱导的体温反应的综合文献综述.
- 分析研究设计,剂量反应数据和机制性途径.
- 评估细胞,器官和生物层面的发现,包括鱼类和动物模型.
主要成果:
- 埃莫丁在各种生物和生物医学文献中始终表现出荷门双相剂量反应.
- 在体内研究中,特别是在鱼类模型中,显示emodin增强了生长,发育和抗压能力.
- 可通用的适应机制包括激活过氧体增殖器激活受体玛和AMPK/Nrf2通路.
结论:
- 埃莫丁在各种生物系统和模型中表现出显著的抑制作用.
- 这些发现凸显了埃莫丁在低剂量时具有有益作用的潜力,在高剂量时存在风险.
- 埃莫丁的阻塞反应由保存的适应途径介导,这表明它具有广泛的生物相关性.
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