对雌性鼠进行力量训练的重复施用oxandrolone的影响
Estéfani Marin1, Nice Vilar Torres2, Maria Manoela Rezende Severo3
1Graduate Program in Biological Sciences: Physiology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
The Journal of steroid biochemistry and molecular biology
|January 31, 2026
概括
在训练期间,牛津罗在雌性大鼠中没有增强强度或肌肉质量. 然而,它导致肝脏损伤和心脏和骨肌肉的组织病理变化,引发了安全问题.
科学领域:
- 运动生理学 运动生理学
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 类固醇类固醇 (AAS) 是合成的衍生物.
- 牛类固醇经常被女性运动员使用,因为它具有合成化合物特性和降低的雄激素性.
- 牛士的毒理效应,特别是与运动相结合,需要进一步调查.
研究的目的:
- 为了评估在接受力量训练的雌性大鼠中oxandrolone的合成代谢效应.
- 在这种情况下,评估oxandrolone管理的毒理概况.
主要方法:
- 24只雌性Wistar大鼠被分为牛类 (1.77mg/kg/天) 和载体组.
- 实施了为期28天的力量训练方案,涉及不同强度的梯子登.
- 分析了体重,器官/肌肉质量,肌肉强度,血液学参数,肝氧化应激标志物和组织病理学.
主要成果:
- 牛津罗没有显著影响体重,器官/肌肉质量或肌肉强度.
- 血液学变化包括改变的平均体质体积和异氨基酸细胞数量;尿素水平增加.
- 肝脏TBARS (thiobarbituric acid反应性物质) 的增加表明脂质过氧化,以及心脏/骨肌肉,脏和上腺的组织病理损伤.
结论:
- 在训练有素的雌性老鼠中,牛罗在强度和质量方面表现出有限的合成代谢益处.
- 显著的毒理发现包括肝脏脂氧化和对重要器官的组织病理损伤.
- 这些结果表明,由于潜在的健康风险,应谨慎使用oxandrolone用于运动或美学目的.
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