在胃内镜下膜剖析期间使用稀释上腺素:国际随机对照试验
Hon Chi Yip1, Noriya Uedo2, Hiroyoshi Iwagami2
1Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR.
Gastrointestinal endoscopy
|January 31, 2026
概括
将稀释的上腺素添加到下注射中,可以显著缩短胃内镜下裂解 (ESD) 程序的时间. 这种方法还可以减少手术内出血,提高早期胃癌治疗的效率和安全性.
科学领域:
- 胃肠病学 胃肠病学
- 内視鏡外科手術 內視鏡外科手術
- 在瘤学瘤学.
背景情况:
- 内镜下粘膜切割 (ESD) 是早期胃癌的标准治疗方法.
- 胃ESD期间的手术内出血可能会延长手术时间.
- 尽量减少出血和手术持续时间对于患者的治疗结果至关重要.
研究的目的:
- 为了评估添加稀释上腺素到下注射溶液的疗效.
- 为了确定上腺素是否会减少胃ESD的手术时间.
- 评估对手术内出血和不良事件的影响.
主要方法:
- 国际,多中心,随机对照试验,涉及800名患者.
- 接受胃ESD的患者被随机分为上腺素或对照组.
- 对手术时间,出血事件和不良事件的盲目评估.
主要成果:
- 与对照组 (68分钟) 相比,上腺素组 (60分钟) 的平均手术时间显著缩短 (p=0.018).
- 需要静血的手术内出血在上腺素组显著较低 (1.8比3.0,p<0.001).
- 两组之间没有观察到术后不良事件的显著差异.
结论:
- 将稀释的上腺素添加到注射溶液中,有效地减少了胃ESD程序的时间.
- 上腺素的使用改善了胃ESD期间的血静.
- 这一战略提高了早期胃癌ESD的效率和安全性.
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