体重指数的分类以及与代谢功能障碍相关的脂肪性肝病和肝脏相关事件的未来风险
Shunming Zhang1, Daniel E Coral2, Zhenyu Huo3
1School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China; Nutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
代谢上不同的体重指数 (BMI) 亚组显示了与代谢功能障碍相关的脂肪性肝病 (MASLD) 和肝脏相关事件 (LREs) 的不同风险. 具有高转氨酶或高血糖的特定亚组表明肝病风险增加.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢健康 代谢健康
- 生物标志物研究 生物标志物研究
背景情况:
- 最近的研究发现了基于心脏代谢生物标志物的五个不一致的身体质量指数 (BMI) 亚组.
- 这些子组偏离了仅基于BMI的预期生物标志物水平.
研究的目的:
- 调查这些独特的BMI亚组与代谢功能障碍相关的脂肪性肝病 (MASLD) 风险之间的关联.
- 检查这些子组与肝脏相关事件 (LREs) 发生率之间的联系.
主要方法:
- 对423,091名参与者进行了前性队列研究.
- 集群分析分类了子群体,反映了之前的研究.
- 事件MASLD和LREs通过电子健康记录进行了跟踪.
- 考克斯的比例危险模型评估了风险 (HR和95%CI).
主要成果:
- 异常高的肝转氨酶和高血糖亚组在男性和女性中显著增加了MASLD和LREs的风险.
- 患有异常高血压的女性,患MASLD的风险较低.
- 对于不一致的不良脂质或炎症概况,没有发现显著的关联.
- 体重指数的分类显示,男性的预测能力更好.
结论:
- 在代谢上不同的BMI亚组对MASLD和LREs具有异质的风险.
- 这些发现强调了考虑代谢概况的重要性,而不仅仅是简单的BMI对肝脏健康的分类.
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