右轨道前皮层rTMS针对焦虑,而不是抑郁,精神分裂症第一发作的症状
YiYi Yang1, Qiang Hu2, Xiong Jiao3
1Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Neuromodulation Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, China; Nantong Fourth People's Hospital and Nantong Brain Hospital, NanTong, Jiangsu 226000, China.
针对右轨道前皮层 (OFC) 的重复性横磁刺激 (rTMS) 有效地减少了第一发精神分裂症 (FES) 患者的焦虑症状. 这种非药理学方法在治疗该群体焦虑症方面显示出有前途.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床试验 临床试验
背景情况:
- 焦虑是第一发精神分裂症 (FES) 中常见且未得到充分治疗的并发症.
- 有限的数据存在于重复性横磁刺激 (rTMS) 对FES.焦虑的疗效.
- 轨道前皮层 (OFC) 在焦虑调节中起着至关重要的作用,使其成为潜在的治疗目标.
研究的目的:
- 为了研究1-Hz右侧OFC-rTMS对FES情绪症状的症状特异性影响.
- 评估rTMS作为针对FES焦虑的有针对性的非药物干预措施.
主要方法:
- 一个随机对照试验的二次分析,涉及未使用药物的FES患者.
- 参与者接受了20次活跃或假的1-Hz右侧OFC-rTMS,并同时接受奥兰扎治疗.
- 用汉密尔顿抑郁评分表 (HAMD),汉密尔顿焦虑评分表 (HAMA) 和正负综合征评分表 (PANSS) 来评估情绪和精神病理症状.
主要成果:
- 活跃的rTMS组与假装组相比,在PANSS总分数和分量表中显示出显著的改善.
- 观察到HAMA总和精神焦虑的显著时间×组相互作用,表明rTMS的有效性.
- rTMS影响了HAMD焦虑/somatization和认知障碍,但没有整体抑郁症状;焦虑和精神病理之间的相关性在活跃组减少.
结论:
- 正确的OFC-rTMS在改善FES患者焦虑症状方面表现出有效性.
- 治疗没有对整体抑郁症状产生特定影响.
- 正确的OFC-rTMS代表了一种有希望的针对性非药物治疗选择,用于FES中的焦虑.
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