在成年早期改变健康生活方式与中年期肥胖性肝病风险的关联
Yun Chen1, Longgang Zhao1, Catherine Mezzacappa2
1Yale School of Nursing, Yale University, Orange, CT, USA.
概括
在成年早期改善健康习惯显著降低了晚年患肝硬性肝病 (SLD) 的风险. 这些好处持续不论遗传倾向肝脏疾病.
科学领域:
- 心血管健康和肝脏疾病研究.
- 公共卫生和生活方式干预.
- 遗传学和疾病风险.
背景情况:
- 众所周知,健康的行为有益于健康,但它们对中年肥胖性肝病 (SLD) 的发展的影响,特别是关于成年早期的生活方式变化和遗传因素,尚未完全理解.
- 年轻成年人冠状动脉风险发展研究 (CARDIA) 为检查长期健康轨迹提供了一个独特的队列.
研究的目的:
- 研究成年早期健康生活方式行为的变化与中年期肥胖性肝病 (SLD) 的发展之间的关联.
- 确定遗传倾向是否改变了成年早期生活方式和中年SLD风险之间的关系.
主要方法:
- 在CARDIA研究中,根据年轻成年人 (18-30岁) 的吸烟,酒精摄入,体力活动和饮食,创建了一个健康的生活方式得分.
- 在7年的时间里,参与者的生活方式变化被分类为 (持续不健康,改善,持续健康).
- 在25年的随访期间,通过非对比腹部计算机断层扫描来评估脂肪性肝病 (SLD).
主要成果:
- 在2,401名参与者中,545人患有SLD. 改善生活方式的人降低了SLD风险 (RR:0.64).
- 与持续不健康的生活方式相比,持续健康的生活方式与较低的SLD风险相关 (RR:0.79).
- 在7年内,健康生活方式得分的每1个点的增加与SLD风险降低15%相关,不论PNPLA3rs738409基因型等遗传风险因素如何.
结论:
- 在成年早期采用和保持健康的行为与中年期患肝硬性病的风险降低有关.
- 健康生活方式对SLD风险的保护作用独立于个体的遗传倾向.
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